1. Institut Curie, Centre de Recherche, 75248 Paris, France;2. CNRS, UMR 218, 75248 Paris, France
Abstract:
Highlights? Spp1 and histone H3K4 residue are important for meiotic DSB formation ? Spp1 physically interacts with the DSB protein Mer2 ? Spp1 in meiosis is not with RNA Pol II, but on chromosome axes in DSB-rich domains ? Spp1’s PHD finger tethers H3K4me3 regions to chromosome axes for DSB formation