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Spp1, a Member of the Set1 Complex,Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes
Authors:Vérane Sommermeyer,Claire Béneut,Emmanuel Chaplais,Maria   Elisabetta Serrentino,Valérie Borde
Affiliation:1. Institut Curie, Centre de Recherche, 75248 Paris, France;2. CNRS, UMR 218, 75248 Paris, France
Abstract:
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  • Highlights? Spp1 and histone H3K4 residue are important for meiotic DSB formation ? Spp1 physically interacts with the DSB protein Mer2 ? Spp1 in meiosis is not with RNA Pol II, but on chromosome axes in DSB-rich domains ? Spp1’s PHD finger tethers H3K4me3 regions to chromosome axes for DSB formation
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