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Phage dUTPases Control Transfer of Virulence Genes by a Proto-Oncogenic G Protein-like Mechanism

Authors:	María Ángeles Tormo-Más Jorge Donderis María García-Caballer Aaron Alt Ignacio Mir-Sanchis Alberto Marina José R Penadés

Institution:	1. Centro de Investigación y Tecnología Animal, Instituto Valenciano de Investigaciones Agrarias (CITA-IVIA), Apdo. 187, 12.400 Segorbe, 12400 Castellón, Spain;2. Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (IBV-CSIC), 46010 Valencia, Spain;3. Departamento de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, 46113 Moncada, Valencia, Spain;4. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 46010 Valencia, Spain

Abstract:	Download : Download high-res image (260KB) Download : Download full-size image Highlights? dUTPases are signaling molecules acting in analogous manner to the G proteins ? Binding to dUTP induces a conformational change in the phage-encoded dUTPases ? The dUTP-bound form of the phage dUTPases induces transfer of virulence genes ? The dUTPase P loop-like motif V is the molecular switch of the signaling mechanism

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