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Insights into FlaI Functions in Archaeal Motor Assembly and Motility from Structures,Conformations, and Genetics
Authors:Sophia Reindl  Abhrajyoti Ghosh  Gareth J Williams  Kerstin Lassak  Tomasz Neiner  Anna-Lena Henche  Sonja-Verena Albers  John A Tainer
Institution:1. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;2. Molecular Biology of Archaea, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany;3. Department of Integrative Structural & Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Highlights? Cross-subunit interface forms building block for transmission of ATPase force ? Structures and mutants reveal functional components for assembly and motility ? The directionality of movement explains FlaI activities and GspE differences ? The phosphate released by ATP hydrolysis triggers subunit rearrangements
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