1. Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA;3. Frick Chemistry Laboratory, Princeton University, Princeton, NJ 08544, USA;4. Department of Biochemistry, Penn State University, PA 16802, USA
Abstract:
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Highlights? ASH2L WH motif is important for trans-regulation of H3 K4 methylation by H2Bub ? Ub stimulates MLL activity in trans, in contrast to DOT1L regulation by H2Bub ? H2Bub enhances MLL, but not MLL3, methyltransferase activity ? H2Aub directly represses MLL methyltransferase activity
