1. University of Lyon, 69000 Lyon, France;2. University Lyon 1, 69000 Lyon, France;3. UMR CNRS 5286, INSERM 1052, Cancer Research Center of Lyon, 69000 Lyon, France;4. UMR INSERM 855, Faculty of Medicine Laennec, 69372 Lyon Cedex 08, France;5. INSERM U1053, University of Bordeaux-Segalen, 146 Rue Léo Saignat, 33076 Bordeaux, France;6. Biochemistry Laboratory of Lyon Sud, Hospices Civils of Lyon, 69495 Lyon, France
Abstract:
Highlights? Transformation-associated glucose shortage triggers ER stress ? The ER stress acts as barrier to malignancy by triggering UPR-dependent apoptosis ? p58IPK expression removes the UPR barrier by attenuating its PERK-CHOP branch ? This adaptive mechanism enables implementation of UPR cytoprotective features