p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose

Authors:	Anne-Laure Huber Justine Lebeau Patricia Guillaumot Virginie Pétrilli Mouhannad Malek Julien Chilloux Frédérique Fauvet Léa Payen Alain Kfoury Toufic Renno Eric Chevet Serge N Manié

Institution:	1. University of Lyon, 69000 Lyon, France;2. University Lyon 1, 69000 Lyon, France;3. UMR CNRS 5286, INSERM 1052, Cancer Research Center of Lyon, 69000 Lyon, France;4. UMR INSERM 855, Faculty of Medicine Laennec, 69372 Lyon Cedex 08, France;5. INSERM U1053, University of Bordeaux-Segalen, 146 Rue Léo Saignat, 33076 Bordeaux, France;6. Biochemistry Laboratory of Lyon Sud, Hospices Civils of Lyon, 69495 Lyon, France

Abstract:	Download : Download high-res image (133KB) Download : Download full-size image Highlights? Transformation-associated glucose shortage triggers ER stress ? The ER stress acts as barrier to malignancy by triggering UPR-dependent apoptosis ? p58^IPK expression removes the UPR barrier by attenuating its PERK-CHOP branch ? This adaptive mechanism enables implementation of UPR cytoprotective features

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