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Two Deubiquitylases Act on Mitofusin and Regulate Mitochondrial Fusion along Independent Pathways

Authors:	Fabian Anton Gunnar Dittmar Thomas Langer Mafalda Escobar-Henriques

Institution:	1. Institute for Genetics, Center for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50674 Cologne, Germany;2. Max Delbrück Center for Molecular Medicine, Berlin 13092, Germany;3. Max-Planck-Institute for the Biology of Aging, Cologne 50931, Germany

Abstract:	Download : Download high-res image (199KB) Download : Download full-size image Highlights? Mitochondrial fusion is regulated by independent ubiquitylation pathways ? The deubiquitylase Ubp2 promotes fusion, whereas Ubp12 inhibits fusion events ? Self-assembly and ubiquitylation cooperatively enable mitochondrial fusion ? Yeast mitofusin is sequentially ubiquitylated

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