1. Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands;2. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA;3. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA;4. The Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA;5. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA;6. California Institute for Quantitative Biosciences, QB3, San Francisco, CA, 94158, USA;7. J. David Gladstone Institutes, San Francisco, CA 94158, USA
Abstract:
Highlights? A resource of genetic modules and networks induced by distinct types of DNA damage ? Networks distinguish DNA damage response pathways with high statistical power ? Rtt109, a histone acetyltransferase, affects the mutagenic bypass of DNA lesions ? The neddylation machinery and Irc21 affect cell-cycle control and genome stability