1. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;2. Instituto de Biología Funcional y Genómica (Consejo Superior de Investigaciones Científicas-Universidad de Salamanca), C/ Zacarías González s/n, 37007 Salamanca, Spain
Abstract:
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Highlights? DSB hot spots for meiotic recombination are specified by largely unknown mechanisms ? Linear element proteins, required for most DSBs, are highly enriched at hot spots ? These proteins, the first known global hot spot determinants, bind without DSB formation ? Hot spot determination by these proteins provides a paradigm for crossover control
