A model of human cardiovascular system containing a loop for the autonomic control of mean blood pressure |
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| Authors: | A. S. Karavaev Yu. M. Ishbulatov A. R. Kiselev V. I. Ponomarenko M. D. Prokhorov S. A. Mironov V. A. Shvartz V. I. Gridnev B. P. Bezruchko |
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| Affiliation: | 1.Chernyshevsky Saratov State University,Saratov,Russia;2.Saratov Branch, Kotelnikov Institute of Radio Engineering and Electronics,Russian Academy of Sciences,Saratov,Russia;3.Razumovsky Saratov State Medical University,Saratov,Russia;4.Bakoulev Scientific Center for Cardiovascular Surgery,Moscow,Russia;5.Central Military Hospital,Federal Security Service of the Russian Federation,Moscow,Russia |
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| Abstract: | We propose a model for the human cardiovascular system that describes the cardiac cycle, the autonomic regulation of heart and vessels, the baroreflex, and the formation of blood pressure. The model also allows for the influence of respiration on these processes. It has been found that an allowance for nonlinearity and insertion of a loop for the autonomic control of mean blood pressure (having the form of selfoscillating time-delay system) enables obtaining model signals with statistical and spectral characteristics that are qualitatively and quantitatively similar to those for experimental signals. The model reproduces the phenomenon of synchronization of the loop for mean blood pressure regulation with a basic frequency of approximately 10 s by the signal of respiration. |
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