Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines. |
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| Authors: | E K Yum S K Kang S S Kim J K Choi H G Cheon |
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| Institution: | Korea Research Institute of Chemical Technology, Yusung, Taejon. |
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| Abstract: | A series of 1-aryl-3-substituted pyrrolo3,2-c]quinolines were synthesized and evaluated for their anti-ulcer activity. While 3-substituents of pyrrolo3,2-c]quinolines mostly affected the in vitro H+/K+ ATPase activity, 1-aryl substituents of pyrrolo3,2-c]quinolines affected the in vivo gastric acid secretion. In addition, the compounds with good in vivo activity protected from ethanol-induced ulcer. |
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