Complexes of some trace metal ions with 5-fluorouracil |
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| Affiliation: | 1. Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy;2. Department of Pharmaceutical, Analytical and Toxicological Chemistry, Kazan State Medical University, Butlerov Street 49, 420012 Kazan, Russian Federation;3. Department of Industrial Engineering, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy;1. Unité des Substances Naturells Bioactives et Biotechnologie, Faculté de Pharmacie de Monastir, Université de Monastir, Rue Avicenne, Monastir 5000, Tunisia;2. Laboratoire de Biologie Moléculaire et Cellulaire, Faculté de Médecine Dentaire de Monastir, Université de Monastir, Monastir, Tunisia;3. Laboratoire d’ingénierie des Biomolécules, ENSAIA-INPL, Université de Lorraine, Vandoeuvre-lès-Nancy, France |
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| Abstract: | The preparation of 5-fluorouracil complexes with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) are reported. The new complexes have been characterised by elemental analysis, solid-state infrared, electronic spectra and magnetic measurements. These measurements suggest that the ligand is bonded to the metal ions through the carbonyl group, behaving as a mono- dentate ligand. On the basis of the ν(OH)bending frequencies and the insolubility of the complexes in common organic solvents, polymeric structures have been proposed for the complexes, with bridging through OH groups. Mn(II), Zn(II) and Cd(II) form four-coordinated complexes, while six coordination numbers have been suggested for Co(II), Ni(II) and Cu(II). |
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