Forskolin-induced cyclic AMP production and gastric acid secretion in dispersed rabbit parietal cells: novel evidence for a major role of cyclic AMP in acid release |
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| Authors: | S Takahashi K Moriwaki S Himeno T Kuroshima Y Shinomura S Hamabe M Kurokawa R Saito T Kitani S Tarui |
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| Affiliation: | 1. Division of Internal Medicine, Department of Clinical Research The Research Institute for Microbial Diseases, Osaka University Yamada-oka, Suita, Osaka, Japan 565;1. The Second Department of Internal Medicine, Osaka University Medical School, Osaka, Japan 553 |
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| Abstract: | Forskolin, a unique diterpine which is a direct activator of cyclic AMP-generating systems, stimulated both cyclic AMP and acid production in dispersed rabbit parietal cells. This agent was also capable of augmenting the action of histamine on both cyclic AMP and acid production at a low concentration. These findings provided novel evidence for a major role of cyclic AMP in gastric acid secretion. |
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