药用真菌活性次级代谢产物研究

药用真菌作为我国传统中医药体系的重要组成部分,有着悠久的历史。它们能够产生丰富的活性次级代谢产物,具有神经保护、抗肿瘤、降血脂等诸多药效。然而,目前对大部分药用真菌次级代谢产物的化学和生物学研究较少。本课题组主要以抗肿瘤、抗炎、抗菌以及抗病毒等生物活性为指导,选择重要药用真菌进行化学研究,构建我国特色药用真菌代谢产物库。文章主要介绍近4年我们在这方面的研究进展。

Bioactive secondary metabolites from medicinal fungi

As an important part of Chinese traditional medicine, medicinal fungi have been used for centuries. They can produce a number of secondary metabolites possessing various bioactivities, such as compounds with neuroprotective effect, anticancer acitvity, and hypolipidemic effect. However, the chemical and biological researches on secondary metabolites from medicinal fungi are not well conducted for most species. In the past four years, we carried out chemical investigations on the medicinal fungi collected in China in order to obtain compounds with anti-cancer, anti-inflammatory, anti-bacterial, and anti-viral biological activities, and build a compound library for medicinal fungi. Herein, the results of our work in recent years are summarized.