Rab cascades and tethering factors in the endomembrane system |
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Authors: | Markgraf Daniel F Peplowska Karolina Ungermann Christian |
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Affiliation: | University of Osnabrück, Department of Biology, Biochemistry Section, Barbarastrasse 13, 49076 Osnabrück, Germany. |
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Abstract: | Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues. |
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Keywords: | Rab GTPases Tethering factor Rab effector Vesicular transport Endomembrane Rab cascade |
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