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Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
Authors:Inoue Hiroshi  Ogawa Wataru  Asakawa Akihiro  Okamoto Yasuo  Nishizawa Akihiko  Matsumoto Michihiro  Teshigawara Kiyoshi  Matsuki Yasushi  Watanabe Eijiro  Hiramatsu Ryuji  Notohara Kenji  Katayose Koji  Okamura Hitoshi  Kahn C Ronald  Noda Tetsuo  Takeda Kiyoshi  Akira Shizuo  Inui Akio  Kasuga Masato
Institution:Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Abstract:STAT3 regulates glucose homeostasis by suppressing the expression of gluconeogenic genes in the liver. The mechanism by which hepatic STAT3 is regulated by nutritional or hormonal status has remained unknown, however. Here, we show that an increase in the plasma insulin concentration, achieved either by glucose administration or by intravenous insulin infusion, stimulates tyrosine phosphorylation of STAT3 in the liver. This effect of insulin was mediated by the hormone's effects in the brain, and the increase in hepatic IL-6 induced by the brain-insulin action is essential for the activation of STAT3. The inhibition of hepatic glucose production and of expression of gluconeogenic genes induced by intracerebral ventricular insulin infusion was impaired in mice with liver-specific STAT3 deficiency or in mice with IL-6 deficiency. These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production.
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