Consequences of early adverse rearing experience (EARE) on development: insights from non-human primate studies

Early rearing experiences are important in one's whole life,whereas early adverse rearing experience (EARE) is usually related to various physical and mental disorders in later life.Although there were many studies on human and animals,regarding the effect of EARE on brain development,neuroendocrine systems,as well as the consequential mental disorders and behavioral abnormalities,the underlying mechanisms remain unclear.Due to the close genetic relationship and similarity in social organizations with humans,non-human primate (NHP) studies were performed for over 60 years.Various EARE models were developed to disrupt the early normal interactions between infants and mothers or peers.Those studies provided important insights of EARE induced effects on the physiological and behavioral systems of NHPs across life span,such as social behaviors (including disturbance behavior,social deficiency,sexual behavior,etc),learning and memory ability,brain structural and functional developments (including influences on neurons and glia cells,neuroendocrine systems,e.g.,hypothalamic-pituitary-adrenal (HPA) axis,etc).In this review,the effects of EARE and the underlying epigenetic mechanisms were comprehensively summarized and the possibility of rehabilitation was discussed.