Haemodynamic and renin responses to prostacyclin infusion in Na depleted and Na restricted sheep |
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| Authors: | R.T. Mason J.P. Coghlan D.A. Denton D.W.T. Fei B.A. Scoggins J.A. Whitworth |
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| Affiliation: | 1. Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, USA;2. Department of Nephrology, The Royal Melbourne Hospital, Parkville, 3052, Australia |
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| Abstract: | The haemodynamic and renin responses to prostacyclin (PGI2) infusion were examined in sheep during sodium depletion and dietary sodium restriction. The haemodynamic effects of PGI2 infusion in sodium depleted and sodium restricted sheep were similar to those obtained in the sodium replete animal. The renin proportionate response to PGI2 was not altered by sodium restriction but blunted by sodium depletion, compatible with the hypothesis that endogenous PGI2 is high in Na depletion. |
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