How cells of repair-deficient mice handle chromosome breaks and proliferate as malignant survivors |
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| Authors: | Debatisse Michelle |
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| Affiliation: | 1. State Key Laboratory of Multi-phase Complex System, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. School of Mathematics, Southwest Jiaotong University, Sichuan 610031, China |
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| Abstract: | Comprehensive studies of complex recurrent translocations leading to pro-B lymphomas in repair-deficient mice demonstrate that amplification of the Myc oncogene by breakage–fusion–bridge (BFB) cycles, initiated as a consequence of site-specific nuclease-induced breaks, are a key step in the progression of this hematologic malignancy. These studies yield new insights into the mechanisms governing genome rearrangement and repair. |
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