Centrosome maturation: Aurora lights the way to the poles |
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| Authors: | Brittle Amy L Ohkura Hiroyuki |
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| Institution: | Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, UK. |
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| Abstract: | The centrosome is the main microtubule organising centre in the cell. During mitosis, centrosomes dramatically increase microtubule nucleating activity, enabling them to form a mitotic spindle. Recent studies show that Aurora A kinase promotes microtubule assembly from centrosomes through the phosphorylation of the conserved centrosomal protein TACC. |
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