2,2',4-trihydroxybenzophenone: crystal structure, and anti-inflammatory and antioxidant activities |
| |
| Authors: | Doriguetto Antônio C Martins Felipe T Ellena Javier Salloum Rogério dos Santos Marcelo H Moreira Maria E C Schneedorf José M Nagem Tanus J |
| |
| Institution: | Laboratório de Cristalografia, Departamento de Ciências Exatas, Universidade Federal de Alfenas-UNIFAL-MG, Rua Gabriel Monteiro da Silva, 714, Alfenas-MG, 37130-000 Brazil. doriguetto@unifal-mg.edu.br |
| |
| Abstract: | The crystal structure of '2,2',4-trihydroxybenzophenone' (=(2,4-dihydroxyphenyl)(2-hydroxyphenyl)methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular H-bonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these anti-inflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure-activity relationship (SAR) of 1 is discussed. |
| |
| Keywords: | Benzophenone 2 2′ 4‐trihydroxy‐ Antioxidant activity Anti‐inflammatory activity X‐Ray crystallography Structure‐activity relationships (SAR) |
| 本文献已被 PubMed 等数据库收录！ |
|
