| Crystal structure determination of alkaline haemorrhagin AaHⅢ from snake venom of Agkistrodon acutus |
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| 摘 要： |
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| 收稿时间： | 1996-05-10 |
Crystal structure determination of alkaline haemorrhagin AaH III from snake venom ofAgkistrodon acutus |
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| WeiminGong,MaikunTeng and LiwenNiu. Crystal structure determination of alkaline haemorrhagin AaH III from snake venom ofAgkistrodon acutus[J]. Science China Life sciences, 1997, 40(4): 351-355. DOI: 10.1007/BF02881727 |
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| Authors: | WeiminGong MaikunTeng LiwenNiu |
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| Affiliation: | (1) The Young Scientist Laboratory of Structure Biology, Department of Biology, University of Science and Technology of China, 230026 Hefei, China;(2) State Key Laboratory of Biomacromolecules, 100080 Beijing, China |
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| Abstract: | The haemorrhagin AaH III isolated from the snake venom ofAgkistrodon acutus is one of the few alkaline ones in snake venoms. Its crystals belong to space group P212121 witha = 9. 573 4 nm,b = 4. 996 7 nm andc = 4.728 8 nm. Its crystal structure was determined by the molecular replacement method according to the model of metalloproteinase Adamalysin II from eastern rattlesnake venom. The AaH III structure has been refined by PROLSQ. The finalR factor was 0.254 and the RMS deviations of bond lengths and angles were 0.001 8 nm and 1.5°. The structure comparison suggested that AaH III has a similar structure to other snake venom zinc-metalloproteinases. They all belong to matrix metalloproteinases super-family. Project supported by the Chinese Academy of Sciences, State Key Laboratory of Biomacromolecules and State Education Commission of China. |
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| Keywords: | crystal structure haemorrhagin metalloproteinase snake venom |
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