The major erythrotropin of bovine Cohn fraction V has the N-terminal sequence of insulin-like growth factor II with isoleucine at position 35 |
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Authors: | L F Congote F Esch |
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Affiliation: | Endocrine Laboratory, Royal Victoria Hospital, Montreal, Canada. |
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Abstract: | The major erythrotropin-like factor of bovine Cohn Fraction V has been isolated from commercial albumin preparations by reversed-phase HPLC. The N-terminal sequence of the major fraction with erythrotropin-like activity is practically identical to the sequence of bovine insulin-like growth factor II. Within the first 45 amino acids, the only difference was the presence of an isoleucine instead of a serine at amino acid 35. This substitution may affect the immunoreactivity of this peptide using antibodies against bovine or human insulin-like growth factor II. |
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