长病程低疾病活动度的系统性红斑狼疮患者血清β2-微球蛋白、肌酐水平与心血管疾病风险的相关性研究

摘要 目的：研究长病程低疾病活动度的系统性红斑狼疮患者血清β2-微球蛋白、肌酐表达水平与心血管疾病风险的相关性。方法：回顾性搜集2017年1月至2022年12月于我院风湿免疫科住院治疗的100例长病程低疾病活动度的系统性红斑狼疮患者作为研究组，并纳入同期健康体检者作为阴性对照组。采用Framingham评分将研究组分为高风险组和低风险组。采用酶联免疫吸附实验检测所有研究对象血清β2-微球蛋白（β2-MG）、肌酐（Scr）的表达水平，采用logistics回归模型分析长病程低疾病活动度的系统性红斑狼疮患者发生心血管疾病的危险因素，采用Pearson检验分析β2-MG、Scr水平与Framingham评分相关性。结果：长病程低疾病活动度的系统性红斑狼疮患者血清β2-MG、Scr表达水平明显升高（P<0.05）；高心血管病风险组长病程低疾病活动度的系统性红斑狼疮患者血清β2-MG、Scr表达水平较低风险组明显升高（P<0.05）；预后情况不同，患者β2-MG、Scr表达水平具有显著差异（P<0.05）；预后良好患者β2-MG、Scr表达水平显著低于预后不良者，预后情况越好，β2-MG、Scr表达水平越低；高危组较低危组代谢综合征比例高、胆固醇及甘油三酯表达水平高（P<0.05）；Framingham评分、β2-MG、Scr是长病程低疾病活动度的系统性红斑狼疮患者发生心血管疾病的危险因素；长病程低疾病活动度的系统性红斑狼疮患者β2-MG、Scr表达水平与Framingham评分正相关。结论：长病程低疾病活动度的系统性红斑狼疮患者血清β2-MG、Scr表达水平与心血管疾病风险正相关。

Correlation between Serum β2-microglobulin and Creatinine (Scr) Levels and Risk of Cardiovascular Disease in Patients with Systemic Lupus Erythematosus with Long Disease Course and Low Disease Activity

ABSTRACT Objective: To investigate the correlation between serum β2-microglobulin and creatinine expression levels and cardiovascular disease risk in patients with systemic lupus erythematosus with long disease course and low disease activity. Methods: A total of 100 patients with systemic lupus erythematosus with long disease course and low disease activity who were hospitalized in the rheumatology and immunology department of our hospital from March 2017 to December 2022 were retrospectively collected as the study group, and healthy subjects in the same period were included as the negative control group. Study groups were divided into high risk and low risk groups using Framingham score. Serum expression levels of serum β2-microglobulin (β2-microglobulin, β2-MG) and creatinine (Scr) were determined by enzyme-related immunosorbent assay. The risk factors of cardiovascular disease in patients with systemic lupus erythematosus with long disease course and low disease activity were analyzed by logistics regression model, and the correlation between β2-MG, Scr level and Framingham score was analyzed by Pearson test. Results: Serum β2-MG and Scr expression levels were significantly increased in patients with systemic lupus erythematosus with low disease activity (P<0.05). Serum β2-MG and Scr expression levels in patients with high risk of cardiovascular disease and long course of low disease activity were significantly increased in patients with systemic lupus erythematosus(P<0.05). The expression levels of β2-MG and Scr were significantly different in patients with different prognosis(P<0.05). The expression levels of β2-MG and Scr in patients with good prognosis were significantly lower than that in patients with poor prognosis. The better the prognosis, the lower the expression levels of β2-MG and Scr. The proportion of metabolic syndrome and the expression levels of cholesterol and triglyceride in high-risk group were higher than that in low-risk group(P<0.05). Framingham score, β2-MG and Scr are risk factors for cardiovascular disease in patients with systemic lupus erythematosus with long course and low disease activity. The expression levels of β2-MG and Scr in patients with long disease course and low disease activity were positively correlated with Framingham score. Conclusion: Serum β2-MG and Scr expression levels are positively correlated with the risk of cardiovascular disease in patients with long disease course and low disease activity.