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Early steps of metabolism evolution inferred by cladistic analysis of amino acid catabolic pathways
Authors:Cunchillos Chomin  Lecointre Guillaume
Institution:Institut Charles-Darwin-International, BP 70, 93230 Romainville, France.
Abstract:Among abiotic molecules available in primitive environments, free amino acids are good candidates as the first source of energy and molecules for early protocells. Amino acid catabolic pathways are likely to be one of the very first metabolic pathways of life. Among them, which ones were the first to emerge? A cladistic analysis of catabolic pathways of the sixteen aliphatic amino acids and two portions of the Krebs cycle is performed using four criteria of homology. The cladogram shows that the earliest pathways to emerge are not portions of the Krebs cycle but catabolisms of aspartate, asparagine, glutamate, glutamine, proline, arginine. Earliest enzymatic catabolic functions were deaminations and transaminations. Later on appeared enzymatic decarboxylations. The consensus tree allows to propose four time spans for catabolism development and corroborates the views of Cordón in 1990 about the evolution of catabolism.
Keywords:aminoacids  cladistic analysis  catabolism  evolution of metabolism  acides aminés  analyse cladistique  catabolisme  évolution du métabolisme
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