The meiotic-9 (mei-9) mutants of Drosophila melanogaster are deficient in repair replication of DNA |
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Authors: | T D Nguyen and J B Boyd |
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Institution: | (1) Department of Genetics, University of California, 95616 Davis, California, USA |
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Abstract: | Summary Repair replication of DNA has been studied in first instar larvae and cultured cells of meiotic-9 (mei-9) mutants in Drosophila melanogaster. Results obtained with both experimental systems show that the mei-9 mutants are defective in this form of repair after UV and X-ray treatment. This defect is correlated with the observation that male larvae carrying alleles of this locus are hypersensitive to killing by UV and X-rays. These findings strengthen the suggestion derived from genetic data that the normal mei-9
+ function is involved in the exchange process of meiotic recombination rather than in a precondition to exchange (Carpenter and Sandler, 1974).Abbreviations FdUrd
5-fluorodeoxyuridine
- BrdUrd
5-bromodeoxyuridine
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3H-dThd
thymidine methyl-3H
- SSC
0.15 M sodium chloride-0.015 M sodium citrate
- UV
ultraviolet radiation-predominantly 254 nm |
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Keywords: | |
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