MORC2 Interactome: Its Involvement in Metabolism and Cancer |
| |
| Authors: | Rohith Kumar Guddeti Namita Chutani Suresh B. Pakala |
| |
| Affiliation: | Biology Division, Indian Institute of Science Education and Research (IISER) Tirupati, Karakambadi Road, Mangalam, Tirupati, Andhra Pradesh 517 507 India |
| |
| Abstract: | Microrchidia 2 (MORC2) is an emerging chromatin modifier with a role in chromatin remodeling and epigenetic regulation. MORC2 is found to be upregulated in most cancers, playing a significant role in tumorigenesis and tumor metastasis. Recent studies have demonstrated that MORC2 is a scaffolding protein, which interacts with the proteins involved in DNA repair, chromatin remodeling, lipogenesis, and glucose metabolism. In this review, we discuss the domain architecture and cellular and subcellular localization of MORC2. Further, we highlight MORC2-specific interacting partners involved in metabolic reprogramming and other pathological functions such as cancer progression and metastasis. |
| |
| Keywords: | MORC2 Chromatin modifiers Interacting partners Metabolism Cancer |
|
|
