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Macrophage function in tumor-bearing mice: dissociation of phagocytic and chemotactic responsiveness |
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| Authors: | M S Meltzer M M Stevenson |
| Institution: | Department of Tumor Biology, Karolinska Institute, S-104 01 Stockholm, Sweden |
| Abstract: | Infusion of CBA mice with lymphoid cells from the H-2 compatible but Mls-antigen incompatible C3H × CBA hybrid results in a specifically reduced capacity of the recipients lymphocytes to react in the MLC against C3H-cells. Although this reduction is immunologically specific the results of this investigation have shown that such mice exhibit a strongly reduced capacity to produce humoral antibodies against heterologous erythrocytes and a T-cell independent antigen (PVP). |
| Keywords: | PC peritoneal cells FCS fetal calf serum LDCF lymphocyte-derived chemotactic factor EAMS endotoxin activated mouse serum BCG HEPES N-2-hydroxyethylpiperazine-N′-2-ethan sulfonic acid sem standard error of the mean SDS sodium dodecyl sulfate VBS-gel All correspondence should be addressed to: Dr Monte S Meltzer M D Building 37 Room 2C20 National Institutes of Health Bethesda Maryland 20014 |
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