CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion |
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Authors: | Aichele Peter Unsoeld Heike Koschella Marie Schweier Oliver Kalinke Ulrich Vucikuja Smiljka |
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Affiliation: | Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany. peter.aichele@uniklinik-freiburg.de |
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Abstract: | The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with recombinant vaccinia virus expressing LCMV glycoprotein, P14 T cell expansion was considerably less dependent on type I IFNR expression. Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections. |
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