|
|||||
|
|
Negative control elements of the cell cycle in human tumors |
|
| Authors: | Peter D Adams William G Kaelin Jr |
| Institution: | aFox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19104, USA;bDana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA |
| Abstract: | The retinoblastoma protein and p53 are both cell-cycle regulators and are, directly or indirectly, inactivated in the majority of human tumors. Recent studies have provided new mechanistic insights into how these proteins regulate cell growth in response to various intracellular and extracellular signals. |
| Keywords: | Abbreviations: APC anaphase promoting complex/cyclosome ATM ataxia telangiectasia mutated ATR ATM related Cdk cyclin-dependent kinase HDAC histone deactylase HPV human papilloma virus RB retinoblastoma TSA trichostatin A |
| 本文献已被 ScienceDirect 等数据库收录！ | |