Amplified, overexpressed and rearranged epidermal growth factor receptor gene in a human astrocytoma cell line |
| |
| Authors: | J Filmus M N Pollak J G Cairncross R N Buick |
| |
| Affiliation: | 1. Department of Materials Science and Engineering, University of Illinois at Urbana–Champaign, 1304 W Green Street, Urbana, IL 61801, USA;2. Division of Hematology-Oncology, Systems Immunobiology Laboratory, Children''s Center for Cancer and Blood Diseases, Children''s Hospital Los Angeles, Los Angeles, CA 90027, USA;3. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou 215123, PR China |
| |
| Abstract: | We report here that SK-MG-3, a human astrocytoma cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified and overexpressed EGF receptor gene. Northern blot analysis did not show any abnormal EGF receptor gene-related mRNA species. No amplification or rearrangement was noted in 21 other astrocytoma cell lines. In contrast to other cell lines that have EGF receptor gene amplifications, we have not detected inhibition of in vitro proliferation of the SK-MG-3 line by EGF. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
