Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme. |
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| Authors: | J Holms K Mast P Marcotte I Elmore J Li L Pease K Glaser D Morgan M Michaelides S Davidsen |
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| Institution: | Cancer Research Area, Abbott Laboratories, Dept. 47J, Bldg. AP10, 100 Abbott Park Road, Abbott Park, IL 60064, USA. james.holms@abbott.com |
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| Abstract: | Modification of the P(1)' substituent of macrocyclic matrix metalloproteinase (MMP) inhibitors provided compounds that are selective for inhibition of tumor necrosis factor-alpha converting enzyme (TACE) over MMP-1 and MMP-2. Several analogues potently inhibited the release of TNF-alpha in a THP-1 cellular assay. Compounds containing a trimethoxyphenyl group in the P(1)' substituent demonstrated TACE selectivity across several series of hydroxamate-based inhibitors. |
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