The proliferative human monocyte subpopulation contains osteoclast precursors |
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| Authors: | Roya Lari Peter D Kitchener John A Hamilton |
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| Affiliation: | (1) Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia;(2) Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, 3010, Australia |
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| Abstract: | Introduction Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyte subpopulations may have special or restricted functions, including as osteoclast precursors. |
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