Relationship between the hydrophobic and hydrophilic molecular parameters of some monoamine oxidase inhibitory drugs, determined by means of adsorptive and reversed-phase thin-layer chromatography. |
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Authors: | T Cserháti K Magyar |
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Institution: | Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest. |
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Abstract: | The absorption capacity, the specific hydrophilic surface area, the lipophilicity and the specific hydrophobic surface area of 17 monoamine oxidase inhibitory drugs were determined by means of adsorptive and reversed-phase thin-layer chromatography for future application of these molecular parameters in quantitative structure-activity relationship studies. Principal component analysis suggests that most of the physicochemical parameters have a different information content, and their application in the elucidation of their mode of action is therefore justified. |
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