Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model |
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| Authors: | Singh Fateh V Chaurasia Sumit Joshi Maya D Srivastava Arvind K Goel Atul |
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| Affiliation: | Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2-one and 6-(furan-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model. |
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