Discovery of a natural thiamine adenine nucleotide |
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| Authors: | Bettendorff Lucien Wirtzfeld Barbara Makarchikov Alexander F Mazzucchelli Gabriel Frédérich Michel Gigliobianco Tiziana Gangolf Marjorie De Pauw Edwin Angenot Luc Wins Pierre |
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| Institution: | Center for Cellular and Molecular Neurobiology, University of Liège, Avenue de l'H?pital 1, B-4000 Liège, Belgium. l.bettendorff@ulg.ac.be |
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| Abstract: | Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues. |
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