Effect of magnesium deficiency on the metabolism of glycosamino-glycans in rats |
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Authors: | Jaya P Kurup P A |
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Institution: | (1) Department of Biochemistry, University of Kerala, Kariavattom, 695 581 Trivandrum, India |
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Abstract: | Magnesium deficiency in rats has significant effect on the concentration of different glycosaminoglycans in the tissues, the
nature of the change being different in different tissues. Total glycosaminoglycans, chondroitin-4-sulphate + chondroitin-6-sulphate
and dermatan sulphate increased in the aorta while hyaluronic acid, heparan sulphate and heparin decreased. In the liver,
total glycosaminoglycans, hyaluronic acid, chondroitin-4-sulphate + 6-sulphate and heparin decreased while total glycosamino-glycans
and all the glycosaminoglycan fractions increased in the heart. In the kidney, total glycosaminoglycans showed no significant
alteration, hyaluronic acid and heparin decreased while chondroitin-4-sulphate + 6-sulphate increased. Activity of biosynthetic
enzymesviz. glucosamine-o-phosphate isomerase and UDPG-dehydrogenase showed decrease in the liver. The concentration of 3’-phosphoadenosine
5’-phosphosulphate, activity of sulphate activating system and sulphotransferase were also similarly altered in the liver
in magnesium deficiency. |
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Keywords: | Magnesium deficiency hyaluronic acid heparan sulphate chondroitin-4-sulphate chondroitin-6-sulphate dermatan sulphate heparin biosynthetic enzyme sulphation |
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