Aging and rat brain muscarinic receptors as measured by quinuclidinyl benzilate binding |
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Authors: | Anne M Morin Claude G Wasterlain |
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Institution: | (1) Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, California;(2) Department of Neurology and Brain Research Institute School of Medicine, University of California, Los Angeles, California |
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Abstract: | Measurement of cholinergic muscarinic receptor binding in various rat brain areas using the ligand 3H]quinuclidinyl benzilate indicates that receptor binding is decreased in striatum and cerebellum of aged female rats (22 months old) as compared to younger rats (4 months old). Decreases were not observed in cortex, hippocampus, hypothalamus, or amygdala areas. Further examination of 3H]quinuclidinyl benzilate binding in subcellular fractions of aged and young rat cerebellum and striatum indicated a decrease in binding in the crude nuclear and crude synaptosomal fractions. Binding data indicate the observed decrease in specific ligand binding is due to a decrease in number of binding sites while receptor affinity does not appear to change.Supported by the Research Service of the Veterans Administration and by Research Grant NS 13227 from NINCDS. |
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