Confounding B-cell defences: lessons from a staphylococcal superantigen |
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Authors: | Silverman Gregg J Goodyear Carl S |
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Affiliation: | Rheumatic Disease Core Center, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0663, USA. gsilverman@ucsd.edu |
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Abstract: | Studies of microbial superantigens that target large clonal sets of B cells through conserved antigen-receptor-variable-region sites are providing new insights into the mechanisms of B-cell activation-induced cell death. These investigations have shown differences between the clonal regulation of follicular B cells (B2 cells) and the innate-like marginal-zone B cells and B1 cells, and have also shown how B-cell superantigens can affect specialized host defences against infection. Agents designed to emulate the properties of B-cell superantigens might also provide new approaches for the treatment of B-cell-mediated autoimmune and neoplastic diseases. |
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