The Na,K-ATPase of nervous tissue |
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Authors: | William L Stahl |
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Institution: | a Neurochemistry Laboratory, V.A. Medical Center, Seattle, Wash., U.S.A. b Departments of Medicine (Neurology) and Physiology and Biophysics, University of Washington School of Medicine, Seattle, Wash., U.S.A. |
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Abstract: | The Na,K-ATPase has been only partially purified from nervous tissue, yet it is clear that two forms (and +) of the catalytic subunit are present. is a component subunit of the glial Na,K-ATPase, which has a relatively low affinity for binding cardiac glycosides and + has been identified as a subunit of the Na,K-ATPase which has relatively high affinity for cardiac glycosides. The + form may also be sensitive to indirect modulation by neurotransmitters or hormones. The ratio of + / changes in the nervous system during development, and + appears to be the predominant species in adult neurones. Changes in Na,K-ATPase activity have been associated with several abnormalities in the nervous system, including epilepsy and altered nerve conduction velocity, but a causal relationship has not been definitively established. Although the Na,K-ATPase has a pivotal role in Na+ and K+ transport in the nervous system, a special role for the glial Na,K-ATPase in clearing extracellular K+ remains controversial. |
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