Linking Hebb's coincidence-detection to memory formation |
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| Authors: | Tsien J Z |
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| Institution: | Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA. jtsien@princeton.edu |
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| Abstract: | The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain. |
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