Effects of stress on release of dopamine and serotonin in the striatum of spontaneously hypertensive rats: an in vivo voltammetric study |
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| Authors: | Masato Ikeda Yoko Hirata Keisuke Fujita Masanori Shinzato Hisahide Takahashi Shigeru Yagyu Toshiharu Nagatsu |
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| Affiliation: | 1. Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, Yokohama 227, Japan;2. Institute for Comprehensive Medical Science, School of Medicine, Fujita-Gakuen University, Toyoake, Aichi 470-11, Japan |
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| Abstract: | By use of in vivo voltammetry technique, in vivo release of dopamine and serotonin in the striatum under stress was found to be more prominent in spontaneously hypertensive rats (SHR) at 4 weeks of age than in control Wistar-Kyoto rats (WKY). Simultaneously, a greater activation of tyrosine hydroxylase in the striatum was demonstrated in SHR than in WKY. These results indicate that SHR is more susceptible to stress in the central monoaminergic neurons than WKY. |
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| Keywords: | Author to whom correspondence should be addressed. |
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