Population and pharmacogenetic studies on serum cholinesterase (E): estimates of theE 1 andE 2 allele frequencies for the population of Central Italy,and of the correlation between E activity and sensitivity to succinylcholine (SCC) |
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Authors: | G. Modiano G. Cermele C. Santolamazza S. Biagioni G. Scarsella L. E. Pacifici G. Toschi |
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Affiliation: | 1. Dipartimento di Biologia, Università ?Tor Vergata?, Roma 2. VI Clinica Chirurgica, Università ?La Sapienza?, Roma 3. Centro di Genetica Evoluzionistica, C.N.R., Roma 4. Istituto di Istologia e Analisi di Laboratorio, Università di Urbino, Urbino, Italy 5. Dipartimento di Biologia Cellulare e dello Sviluppo, Università ?la Sapienza?, Roma
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Abstract: | 392 random patients treated with SCC prior to surgery were assayed for pseudocholinesterase activity and electrophoretic pattern. The estimate of the percent frequencies of theE 1 a allele were 1.16±0.38 and of the C5 (+) phenotype 9.7±1.5, both typical of Caucasian populations. By combining the presentE 1 a gene frequency estimate with that from another sample of the same population (Cermele et al., 1987) a better estimate with smaller confidence limits was obtained, that is: 1,14±0,27. One subject interpreted asE 1 a E 1 a on phenotypic grounds was also found (expected 0,05) in this random sample. A correlation coefficient of −0.521 was found between E activity and myorelaxation time in the whole sample. High correlation values (r=−0.55 and r=−0.46) were found forE 1 u E 1 u ; C5 (−) andE 1 u E 1 u ; C5 (+) individuals, respectively, showing a strong dependence of the latter variable on the former one even within apparently homogeneous classes. The use of the product of these two variables as a classification criterion allowed the identification of a subject with very long myorelaxation time but normal activity. |
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Keywords: | Human serum cholinesterase Suecinylcholine sensitivity Population study |
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