体外抑制EB病毒药物的应用研究

EB病毒容易感染人,与人类许多疾病高度相关,严重威胁人类健康。目前尚无有效的预防EB病毒感染的措施且针对EB病毒的药物比较局限,故而对EB病毒感染进行治疗显得十分重要。近年来研究发现,许多药物在体外可对EB病毒有很好的抑制效果。仅就体外抑制EB病毒的药物,如核苷类似药、硼替佐米、寡脱氧核苷酸、乳铁蛋白、砷剂、维生素甲类化合物、亚硒酸钠、某些中草药等的近期研究现状进行综述。

Applications of anti-Epstein-Barr virus drugs in vitro

Epstein-Barr virus, a human herpesvirus IV, is susceptible to the human, and is highly association with some diseases. However, it is difficult to prevent and treat infection of Epstein-Barr virus. Recently, studies have found that many drugs in vitro play roles in inhibitory effect on Epstein-Barr virus infection. The mechanisms of anti-viral drugs may include interfering infection route, or inhibiting viral replication or enhancing cell killing effect and regulating specific cellu- lar immune. Therefore, the drugs exhibit broad application prospects in vitro, and showed a good trend for clinical preven- tion and control of the infection and associated diseases . In this paper, we briefly overview the inhibitory effect in vitro of drugs on Epstein-Barr virus infection.