The crosstalk between EGF,IGF, and Insulin cell signaling pathways - computational and experimental analysis |
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| Authors: | Rafal Zielinski Pawel F Przytycki Jie Zheng David Zhang Teresa M Przytycka Jacek Capala |
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| Institution: | (1) National Cancer Institute National Institutes of Health, Bethesda, MD, USA;(2) Columbia College Columbia University New York, NY, USA;(3) National Center for Biotechnology Information, National Library of Medicine National Institutes of Health Bethesda, MD, USA;(4) Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, USA |
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| Abstract: | Background Cellular response to external stimuli requires propagation of corresponding signals through molecular signaling pathways.
However, signaling pathways are not isolated information highways, but rather interact in a number of ways forming sophisticated
signaling networks. Since defects in signaling pathways are associated with many serious diseases, understanding of the crosstalk
between them is fundamental for designing molecularly targeted therapy. Unfortunately, we still lack technology that would
allow high throughput detailed measurement of activity of individual signaling molecules and their interactions. This necessitates
developing methods to prioritize selection of the molecules such that measuring their activity would be most informative for
understanding the crosstalk. Furthermore, absence of the reaction coefficients necessary for detailed modeling of signal propagation
raises the question whether simple parameter-free models could provide useful information about such pathways. |
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