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Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq |
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| Authors: | Mehdi Motallebipour Adam Ameur Madhu Sudhan Reddy Bysani Kalicharan Patra Ola Wallerman Jonathan Mangion Melissa A Barker Kevin J McKernan Jan Komorowski Claes Wadelius |
| Institution: | 1. Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskj?lds v?g 20, SE-75185, Uppsala, Sweden 7. MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, W12 0NN, London, UK 2. Linnaeus Centre for Bioinformatics, Uppsala University, Biomedical Center, Husargatan 3, SE-75124, Uppsala, Sweden 8. Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskj?lds v?g 20, SE-75185, Uppsala, Sweden 9. Department of Development and Genetics, EBC, Uppsala University, Norbyv?gen 18, SE-75236, Uppsala, Sweden 3. Applied Biosystems UK, 120 Birchwood Boulevard, WA3 7QH, Warrington, Cheshire, UK 4. Life Technologies, 850 Lincoln Centre Drive, 94404, Foster City, CA, USA 5. Life Technologies, 500 Cummings Center, Suite 2400, Beverly, MA, 01915, USA 6. Interdisciplinary Centre for Mathematical and Computer Modeling, Warsaw University, Krakowskie Przedmie?cie 26/28, 00-927, Warszawa, Poland |
| Abstract: | BackgroundThe forkhead box/winged helix family members FOXA1, FOXA2, and FOXA3 are of high importance in development and specification of the hepatic linage and the continued expression of liver-specific genes. |
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