Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy |
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Authors: | Arbibe Laurence Sansonetti Philippe J |
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Affiliation: | Unité de Pathogénie Microbienne Moléculaire and Unité INSERM 786, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. arbibe@pasteur.fr |
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Abstract: | Tolerance to lipopolysaccharide (LPS) is part of the host's strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit expression of proinflammatory genes while maintaining efficient antimicrobial functions. In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation. |
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