A Reverse genetics system for dsRNA viruses |
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| Authors: | Baric Ralph S Sims Amy C |
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| Affiliation: | Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@emai.unc.edu |
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| Abstract: | The advent of a new reverse genetics system for reoviruses, described in this issue of Cell Host & Microbe by Kobayashi et al., opens new horizons of investigation into the molecular mechanisms governing dsRNA virus replication and pathogenesis. The elegant approach for recombinant reovirus recovery from a set of plasmid DNAs provides a template for designing similar reverse genetics systems for other dsRNA viruses associated with considerable morbidity and mortality in humans. |
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