Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata |
| |
Authors: | Li Lei Ni Wei Li Xing-Rao Hua Yan Fang Ping-Lei Kong Ling-Mei Pan Li-Li Li Yan Chen Chang-Xiang Liu Hai-Yang |
| |
Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. |
| |
Abstract: | By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first pentacyclic sterol glycoside with 6-6-6-5-6 fused rings. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis, including that of 2D NMR data, and the results of acidic hydrolysis. The cytotoxicity of the selected steroidal glycosides (1-4, 8, and 9) was evaluated in vitro against five human cancer cell lines. Compound 9 showed significant inhibitory activity against all five cell lines. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|