Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease |
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Authors: | Chun Yong Soon Chaudhari Pooja Jang Yoon-Young |
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Institution: | Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. |
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Abstract: | The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm- tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy. |
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Keywords: | Stem Cell Disease Modeling Drug Screening Liver Disease |
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